Weight loss(Vegetarian Diet )

                                             Weight loss(Vegetarian Diet )

 So in this subject  maybe is not to eat the panacea the-the-the possible option to achieve longevity and what is very important is of course and that's why we have which met we are convinced that to eat right is the best way to avoid disease but we have to remind that eating and digestion is a very very complex task for the body in fact independently of what we eat in the first place every fruit single item

Is a foreign body for for the body we digest it and it is a huge immunological and inflammatory response that accompanies every digestive process and so it's not weird and and and it's quite clear that if we in any way if we reduce this task for the body there should be some health advantage and the other question is is fasting alcoholic caloric restriction is there intersection with vegan diet with vegetarian diet is there a common trunk not only in the mechanism

But also maybe in the practical translation for our patients and as you might anticipate the question is yes there is a common trunk and I would like to present the data behind that so and one reason why it seems to be look in a global view too healthy to restrict calories to restrict intake is it's a clear fact a large part of the world today just practice overeating we are eating too many calories independently what type but it's just too much and we

Know that overeating has a lot of consequences mainly cardiovascular easy disease we heard diabetes also Alzheimer the multiple sclerosis maybe and even Parkinson and a lot of inflammatory diseases and so these are the choices a reduced lifespan bye-bye disease maybe the average lifespan or a maximum lifespan and this is what science tells us to date that if we practice any type of dietary restriction and I will go more into the details which type of

Dietary restriction seems optimal but this is the summary where you see there are it is the same list that we have here where we may produce benefits and it is a clear that if we summarize the research for the last three decades we don't have that much observations from human studies this starts only since about 10 years but we know it's a clear consistent and homogenous effect that is in any species from bacteria from yeast through to monkeys to to all animals

That if they eat less they live longer and they are less diseased that is very very clear here the only question mark a little bit is still with humans we don't have trials in humans that have an endurance of 49 years or 65 years to really answer the question will people that practice fasting or caloric restriction achieve an age of above 90 or or not we will know that in yeah in some decades yeah but coming back to fasting and caloric restriction

Besides the medical question the scientific question it has a long tradition in human mankind in culture in religion and in spiritual contacts as you will know this is just a selection we have fasting periods in Christianity in India we have Ramadan which will start as soon a of intermittent fasting and all over the world we know that any shamanistic ritual initiation rituals are mainly accompanied by fasting periods starting

Some days before this is just very common and on the other side we have a medical history a tradition even starting with the school of hypocrite but also the traditional Chinese medicine you always will find quotes that we should eat one-third less then how we feel hungry or one or 24% or that we sometimes should completely renounce or should skip meals you will find that in all traditional medical systems in Europe it was about 70 years ago or 90

Years ago when it started to get really implemented in naturopathy in complementary medicine that fasting cures were recommended to treat patients and now we have the nice situation that modern research approaches what we have done in traditional European medicine the last decades but what is fasting and caloric restriction when we look at the experimental research 30 years ago 40 years ago the the working groups of policy in San Luis or the biosphere as

You may know royal war fort they they always proposed energy reduction of 32 to 42percent there's also a group in the United States they practice this every day caloric restriction they're called the Kroners caloric restriction optimum diet they are very skinny in fact so they don't have high proportions of diabetes and they are quite healthy they look very skinny that may be sometimes also a little bit shocking and then we are fasting

We have prolonged fasting it may be up to 30 days like in the Quran I know a lot of page I don't recommend 30 days of fasting but I know that a lot of people are appealed to say oh yes I do it like it is written in the Quran I will fast for 30 days in fact when they succeed then then they see very good results but I think it's a little bit too long we have water only fasting we have choose fasting the method by booting err as many of you will know where you have an Intake of 300 calories a day by Jews or by a vegetable broth maybe 400 but you should not go over 500 because then you stop liberalizes from the liver which is the basis for the different metabolism in fasting then we have short term frosting in oncology at this time we have now very very popular in Great Britain 2 to 5 fasting it was boosted by the BBC journalist Max Mosley he wrote a book eat fast and live longer at this time With patients I think it's much easier to have a period of one week fasting two times a year than to fast every week two days from a social point of view it's not not so easy to if you are invited or if you have a family to say yeah on let's say Sunday or Saturday and Sunday I fast or Monday and Tuesday it's a little bit strict but maybe for some people they are inclined to do that and then it's a healthy thing what is also important we

Had invited professor Longo he's one of the proponents of fasting research in December here in Berlin and shot a charity and from his experiments we asked him what do you think is the most important thing we should do every day to eat healthy and he said you should every day have a 16 hours break of eating so the best way to have would be to have only two meals a day and maybe these two meals in an distance from six hours or seven hours and then to have a

Break of 16 or 18 hours this is the best for the digestive system and for the immunological system to recover from the burden of digestion as I said already but the question is is intermittent fasting and caloric restriction the same regarding health yes it seems to be the same and as I told caloric restriction it's yeah it's it's it's not such a funny thing so intermittent fasting might be more attractive and these are data where you

See intermittent fasting is glucose here's insulin and here are the caloric restriction populations intermittent fasting compares very nicely but even better than caloric restriction and this is also shown in this picture and there's a lot of data that show yes intermittent fasting and caloric restriction are two possibilities with almost the same effects and what we know and this comes back to the first slide yes life is prolonged if here is shown

By the different animal data if intermittent fasting is part of the life this is all and and to remind you that so far there is no other medical intervention no single intervention for which it has been shown to prolong life what we see with very good medical support with surgery with medication is always we can prolong the health span but genetically we have to die yeah the majority between 75 and 90 and this is the the only intervention so far that

Shows that the life span can be prolonged and increased but there are also some clinical effects for fasting I will go through it quickly you see fasting leads to an immediate blood pressure reduction about 20 points here data from a known study of our group also 20 points and this is very nice for patients because sometimes yeah if we saw them we heard dr. Barnard and it was stimulating and but sometimes we know that in in in practical medicine

Effects need a longer time and for our patients sometimes it's very impressive when they start fasting energy wow it's the third day of fasting my blood pressure drops 30 or 40 points I can get rid of the medication so psychologically it's a very strong effect because fasting is so powerful in the first days this is Roma tree detritus a very interesting study now almost twenty over 25 years old but still true where chaos and crack and his co-workers they

Combined fasting over ten days followed by a vegan gluten-free diet for four months and then by a lacto-vegetarian diet and as you see the effects on pain or morning stiffness of the joints or tender joints was maintained over 13 months the problem with this study is we don't know how would it have been with the only lacto-vegetarian diet was gluten-free the first three months important or not we would have needed more comparative arms study arms to

Answer these questions we don't know we just can tell you this fasting combined with a vegan diet produced excellent results for patients with rheumatic inflammation with rheumatic Atreides and this is very exciting what what about the longer did the last years he showed us that if you perform fasting during treatment of a cancer you may reduce the side effects of chemotherapy we replicated this findings that we are first done in animals here in a human

Study and you see a clear effect here is quality of life maintained when you do fasting during chemotherapy and decreases when patients have a regular diet during chemotherapy and here also a nice study from Miss Kali over she is now in Loma Linda she showed us when we reduce in diabetes from six meals per day to two meals a day now I'm coming back to meal skipping we have a bunch of very beneficial effects here on hba1c on CPAP today so again it seems here useful

So when we look at the physiology at the mechanisms behind the beneficial effects of fasting there is a long list you see insulin decreases Dean and this seems to be very important igf-1 here also from Luigi Fontana where's the igf-1 is it's indicated here several times we suppose that the reduction in I G f1 has a prominent role in track in translating these beneficial effects and so I come to the last point of my presentation so what will we gain

Diet or vegetarian vegetarian diet do in this context and there are three points to make the first point is a plant-based diet is also always a diet with a reduced energy density and I've shown this slide yesterday you see when people start a vegan diet with the purpose of reducing weight or not they will lose weight it is because of the reduced energy density so it is a very mild form of dietary restriction the other point is some of the effects of fasting seem

To be only related to the restriction of protein intake I think it was always said is as methionine methionine which is seems to be responsible for a lot of the damaging effects on the on the cell and methionine is mainly in meat and milk and so the restriction on animal protein seems to be partly responsible for the whole effect of dietary restriction which was shown by Luigi Fontana and this data you see if you have a low calorie group that consumes

Animal-based protein and compared them to a group that has low protein it compares very beneficially and here predominantly for igf-1 so we can't say is it 50% or 30% or 70% but the protein restriction seems to be important and here it was the first epidemiological study also done by a Valter Longo and his groups and it's it's not very easy to see her but especially in people aged below 65 there's a clear advantage regarding

Mortality from chronic disease from cardiovascular disease if animal protein intake is reduced and this is a suggestion now from Luigi Fontana where he says well if we are promoting longevity it seems we have reduced calorie intake as one step and we have reduced animal protein intake as a second step of course we also have exercise mental health but we can may be divided into two nutritional principles and this is the last point I want to

Make and coming back to the clinical to the practical side of fasting what we always see is fasting brings good mood people have a very good mood in fasting maybe they feel hungry the first day sometimes the third day but in fact there is a clear mood enhancement visible and this for us is psychological a very nice situation to enhance to support lifestyle modification as we know it is very very difficult to change nutritional habits for our patients most

Fail and again when we have this initial experience it works like a reset button so people don't forget that they said well it is the first time in my life I'm eating nothing or mainly nothing and I feel great and this makes them reflecting that maybe the way they aid did not contribute to their well-being generally and so they then they are capable to change their nutritional habits because they believe and they experience that it has a great

Impact and so here we found in our own data that depression and anxiety and hostility were largely reduced in the course of a fasting cure and we summarized this also in a paper so what are my conclusions fasting appears clearly effective in the in the prevention and treatment of diseases I know that we need more data but if we summarize also the experimental data it's clear very very consistent and I think there will I have no doubt that

The next years we will see more and more data showing us that fasting and caloric restriction are healthy and it is very interesting that we may say a part of the fasting effect can be achieved by a vegan diet or at least by not eating animal protein I don't know we don't know which part I I repeat but clearly it's the best combination and if we think about the data from calcine croc why not combining it also in other inflammatory chronic diseases

Starting a fasting cure followed by a vegan or a lacto-vegetarian diet and this is also very important fasting for me is the ideal promoter of nutritional lifestyle change so at least in Europe I heard from what along go in United States it's not so easy people think all fasting well this is very very very strange and get a little bit anxious but here in Europe with the traditional fasting we see that people loved it and liked it and so I would endorse that

Combination